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14
2024-05

Nature Methods | An invited comment to summarize the opportunities and challenges of biological i...

Advanced imaging techniques provide holistic observations of complicated biological phenomena across multiple scales, while posing great challenges on data analysis. We summarize recent advances and trends in bioimage analysis, discuss current challenges towards better applicability, and envision new possibilities.“More is different.” As indicated by Philip W. Anderson about 50 years ago, the...
14
2024-05

Nature Computational Science | Next-Generation Self-Supervised Denoising Method for Multi-Modal U...

The rapid development of optical imaging technology has enabled researchers to observe the structure and activity of organisms on a micron and even nanometer scale. Fluorescence microscopy, a widely used imaging method, aids in discovering new physiological and pathological mechanisms due to its high spatiotemporal resolution and molecular specificity. The primary goal of fluorescence microscop...
14
2024-05

Nature Biotechnology | Real-time denoising enables high-sensitivity fluorescence time-lapse imagi...

The normal functioning of living organisms relies on a series of spatiotemporally coordinated cellular and subcellular activities. Observing and recording these phenomena is the first step to understanding them. Fluorescence microscopy, combined with the development of fluorescent probes, provides scientists with a tool for high spatiotemporal resolution and molecular specificity. Advances in f...
14
2024-05

Nature Methods | A new self-supervised denoising method to break the shot-noise limit in calcium ...

Calcium imaging allows parallel recording of neural activity in living organisms at single-cell resolution, offering great potential for unraveling the mechanisms of information propagation, integration, and computation in neural circuits. Achieving high signal-to-noise ratio (SNR) calcium imaging data is crucial for accurate neural function analysis. However, the low peak accumulation and rapi...
14
2024-05

Science Advances | All-Optical Encoder-Decoder for High-Performance Image Communication

With the development of an intelligent society, image transmission has become a fundamental need in various fields of daily life. For instance, streaming a Blu-ray movie requires transmission throughput of several gigabits per second. Transmission links need to support such high throughput for numerous terminals simultaneously, posing significant challenges for image transmission. Additionally,...
14
2024-05

Nature | All-analog photoelectronic chip for high-speed vision tasks

01 Introduction Recently, the Imaging and Intelligent Technology Laboratory from the Department of Automation and the Intelligent Sensing Integrated Circuit and System Laboratory from the Department of Electronic Engineering at Tsinghua University have jointly proposed an all-analog photo-electronic integrated computing chip. This chip has, for the first time globally, demonstrated that photo-e...
14
2024-05

Nature | An integrated imaging sensor for aberration-corrected 3D photography

Perfect optical imaging, one of the ultimate goals of human perception of the world, is fundamentally constrained by errors in mirror fabrication and complex environmental disturbances causing optical aberrations. The photonics team uniquely proposed an integrated meta-imaging sensor architecture to carve a new path for solving the aberration challenge. Instead of constructing perfect lenses, t...
14
2024-05

Cell | Two-photon synthetic aperture microscopy for cross-scale spatiotemporal observation of dee...

Two-photon microscopy is indispensable for in vivo observation of deep, scattering tissues, with its superior penetration depth compared to single-photon imaging being widely recognized in life sciences and medical research. However, traditional point-scanning two-photon imaging fundamentally limits imaging throughput and three-dimensional perception speed, making it highly susceptible to inter...

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