Qionghai Dai is a professor in Tsinghua University, and the academician of Chinese Academy of Engineering. He has made pioneering contributions in developing mesoscale intravital fluorescence microscopy, artificial intelligence methods for biomedical applications, and optical computing techniques. He built the world’s first gigapixel fluorescence microscope that achieves cortex-wide neural recording at subcellular resolution in mammals, facilitating the interrogation of neural circuits, as well as many other biological dynamics. He is also leading the direction of neuromorphic optoelectronic computing with distinguished contributions such as diffractive processing unit and all-analog optoelectronic chips, offering a promising avenue for next-generation computing architecture.